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1999:
Nakamura T; Matsuzaki G; Nomoto K
The protective role of T-cell receptor Vgamma1+ T cells in primary infection with Listeria monocytogenes.
Immunology 1999;
96(
1):.
We have previously reported that the T-cell receptor (TCR) gamma delta+ T cells increase in mice infected with an intracellular bacteria Listeria monocytogenes, and the cells predominantly express Vdelta6 and Vgamma1 genes. In this study, we used a monoclonal antibody (mAb) specific to TCR Vgamma1 to estimate the frequency of Vgamma1+ T cells and we discuss their significance in protection against L. monocytogenes. The spleen, liver and peritoneal exudate cells from mice intraperitoneally infected with L. monocytogenes were analysed by flow cytometry. In all the organs investigated, Vgamma1+ cells increased predominantly among TCR gamma delta+ T cells at an early phase (day 5-7) of the infection. To elucidate the significance of the Vgamma1+ T cells in the protection against L. monocytogenes, mice were depleted of TCR Vgamma1+ gamma delta T cells or all TCR gamma delta+ T cells by intraperitoneal inoculation of anti-Vgamma1 mAb or anti-pan TCR gamma delta mAb, respectively, before infection with L. monocytogenes. The bacterial growth in the spleen and the liver examined on day 5 after the infection increased significantly by the depletion of TCR Vgamma1+ T cells. The numbers of L. monocytogenes in TCR Vgamma1+ T-cell-depleted mice were nearly the same as in mice depleted of all TCR gamma delta+ T cells. These results demonstrated that Vgamma1+ T cells are the predominant population of gamma delta T cells in protection against L. monocytogenes at the early phase of the primary infection.
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