Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1,800,000 Profiles
- More than 3,500 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
find experts for
Sign-in to see more
1999:
Hamada K; Nagai S; Tsutsumi T; Izumi T
Bone mineral density and vitamin D in patients with sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders 1999;
16(
2):.
BACKGROUND AND AIM OF THE WORK: Imbalance of calcium homeostasis has ben frequently detected in sarcoidosis patients. In our previous study abnormal metabolism of calcium was detected in about 40% of the patients. In the current study, bone mineral density (BMD) was investigated in relation to serum concentration of calcium and vitamin D. METHODS: Consecutive groups of fifteen men (40 +/- 12 years, as mean +/- SD) and 18 women (51 +/- 11 years) with histologically proven sarcoidosis who had not been treated with corticosteroids prior to the study were studied together with control groups. BMD was measured with dual-energy X-ray absorptiometry (DXA) of lumbar vertebrae, and the Z score was calculated to avoid bias of sex and age. Serum concentrations of ionized calcium (s Ca2+), 1,25-Dihydroxyvitamin D (s1, 25(OH)2D3) and osteocalcin (sOC) were measured at the same time. RESULTS: In women with sarcoidosis only, sCa2+ and s1,25(OH)2D3 showed inverse correlations with Z score of BMD (r = 0.482, p < 0.05 and r = -0.635, p < 0.01, respectively), and s1,25(OH)2D3 showed a positive correlation with sOC (r = 0.658, p < 0.01). Multiple regression analysis showed that age and s1,25(OH)2D3 were the contributory factors to BMD in female patients. Such a significant correlation was not observed in men with sarcoidosis or controls. CONCLUSIONS: 1,25(OH)2D3 seemed to be contributory to accelerated turnover of the bone and reduction of BMD in women with sarcoidosis.
Post to CiteULike 
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
