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2000:
Barzik M; Schubert W D; Carl U; Wehland J; Heinz D W
Crystallization and preliminary X-ray analysis of the EVH1 domain of Vesl-2b.
Acta crystallographica. Section D, Biological crystallography 2000;
56(
Pt 7):.
Proteins of the Homer/Vesl family are enriched at excitatory synapses and selectively bind to a proline-rich consensus sequence in group 1 metabotropic glutamate receptors via a domain that shows a strong similarity to the Ena/VASP homology 1 (EVH1) domains. EVH1 domains play an important role in actin cytoskeleton dynamics. Crystals of the EVH1 domain of murine Vesl-2b were obtained that diffract X-rays to 2.4 A resolution. They belong to space group C2, with unit-cell parameters a = 112.8, b = 69.9, c = 54.9 A, beta = 110.7 degrees, consistent with three molecules per asymmetric unit and a solvent content of 53%.
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