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2000:
Silveira D C; Holmes G L; Schachter S C; Geula C; Schomer D L
Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.
Brain research 2000;
878(
1-2):.
We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures.
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