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2001:
Sermet-Gaudelus I; Lesne-Hulin A; Lenoir G; Singlas E; Berche P; Hennequin C
Sputum itraconazole concentrations in cystic fibrosis patients.
Antimicrobial agents and chemotherapy 2001;
45(
6):.
Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range.
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