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2001:
Kretschmar M; Geginat G; Bertsch T; Walter S; Hof H; Nichterlein T
Influence of liposomal amphotericin B on CD8 T-cell function.
Antimicrobial agents and chemotherapy 2001;
45(
8):.
Liposomal amphotericin B was immunosuppressive on target cell lysis in vitro and on protection mediated by cytotoxic CD8 T cells in murine listeriosis. When dosages usually used for therapy in humans were compared, the immunosuppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/day was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosage of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.
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