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2001:
Minenkova O; Gargano N; De Tomassi A; Bellintani F; Pucci A; Fortugno P; Fuscaldi E; Pessi A; Rapicetta M; Miceli M; Iudicone P; Cortese R; Felici F; Monaci P
ADAM-HCV, a new-concept diagnostic assay for antibodies to hepatitis C virus in serum.
European journal of biochemistry / FEBS 2001;
268(
17):.
We screened phage libraries using sera from noninfected individuals and patients infected by hepatitis C virus (HCV). By applying different selection and maturation strategies, we identified a wide collection of efficient phage-borne ligands for HCV-specific antibodies. The selected ligands retained their antigenic properties when expressed as multimeric synthetic peptides. Peptides that mimic several immunodominant epitopes of the virus were used to develop a novel type of diagnostic assay which efficiently detects antibodies to HCV in serum. This type of analysis provides a conclusive diagnosis for many patients identified as indeterminate according to presently available serological assays.
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