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2002:
Bauerschmitz Gerd J; Lam John T; Kanerva Anna; Suzuki Kaori; Nettelbeck Dirk M; Dmitriev Igor; Krasnykh Victor; Mikheeva Galina V; Barnes Mack N; Alvarez Ronald D; Dall Peter; Alemany Ramon; Curiel David T; Hemminki Akseli
Treatment of ovarian cancer with a tropism modified oncolytic adenovirus.
Cancer research 2002;
62(
5):.
Ad5-Delta 24RGD is an adenovirus that is selectively replication competent in cells defective in the Rb/p16 pathway, such as ovarian cancer cells. The fiber of Ad5-Delta 24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of cancer cells. Oncolysis of cell lines was similar to that of a wild-type control, and replication in primary tumor material was shown using a novel three-dimensional spheroid model. Finally, an orthotopic murine model of peritoneally disseminated ovarian cancer was used to test i.p. administration to tumor-bearing animals. Injection of the agent resulted in eradication of i.p. disease, whereas control animals expired (P < 0.0001). These results suggest that Ad5-Delta 24RGD could be useful for treatment of ovarian cancer in humans.
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