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2002:
Nadon Celine A; Bowen Barbara M; Wiedmann Martin; Boor Kathryn J
Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes.
Infection and immunity 2002;
70(
7):.
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes.
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