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2002:
Shchelkunov S N; Totmenin A V; Safronov P F; Mikheev M V; Gutorov V V; Ryazankina O I; Petrov N A; Babkin I V; Uvarova E A; Sandakhchiev L S; Sisler J R; Esposito J J; Damon I K; Jahrling P B; Moss B
Analysis of the monkeypox virus genome.
Virology 2002;
297(
2):.
Monkeypox virus (MPV) belongs to the orthopoxvirus genus of the family Poxviridae, is endemic in parts of Africa, and causes a human disease that resembles smallpox. The 196,858-bp MPV genome was analyzed with regard to structural features and open reading frames. Each end of the genome contains an identical but oppositely oriented 6379-bp terminal inverted repetition, which similar to that of other orthopoxviruses, includes a putative telomere resolution sequence and short tandem repeats. Computer-assisted analysis was used to identify 190 open reading frames containing >/=60 amino acid residues. Of these, four were present within the inverted terminal repetition. MPV contained the known essential orthopoxvirus genes but only a subset of the putative immunomodulatory and host range genes. Sequence comparisons confirmed the assignment of MPV as a distinct species of orthopoxvirus that is not a direct ancestor or a direct descendent of variola virus, the causative agent of smallpox.
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