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2002:
Hirota Kosaku; Kazaoka Kazunori; Niimoto Itaru; Kumihara Hiroshi; Sajiki Hironao; Isobe Yoshiaki; Takaku Haruo; Tobe Masanori; Ogita Haruhisa; Ogino Tetsuhiro; Ichii Shinji; Kurimoto Ayumu; Kawakami Hajime
Discovery of 8-hydroxyadenines as a novel type of interferon inducer.
Journal of medicinal chemistry 2002;
45(
25):.
9-Benzyl-8-hydroxyadenine (6) was found to possess interferon-inducing activity in vitro as a lead compound. Although replacement of the 9-benzyl group of 6 did not improve the activity, the introduction of a substituent such as alkyl, alkylthio, alkylamino, and alkoxy groups into the 2-position of the adenine ring resulted in a remarkable increase in the activity. The 2-alkylthio (30-32), 2-butylamino (41), and 2-butoxy (47) analogues indicated the highest activities by oral administration to mice.
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