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2003:
Aldieri Elisabetta; Atragene Daniela; Bergandi Loredana; Riganti Chiara; Costamagna Costanzo; Bosia Amalia; Ghigo Dario
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.
FEBS letters 2003;
552(
2-3):.
Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.
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