Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
find experts for
Sign-in to see more
2003:
Kolb-Mäurer Annette; Goebel Werner
Susceptibility of hematopoietic stem cells to pathogens: role in virus/bacteria tropism and pathogenesis.
FEMS microbiology letters 2003;
226(
2):.
Human hematopoietic stem cells (HSCs) are generated in the bone marrow and differentiate into erythrocytes, granulocytes, monocytes, megacaryocytes, and lymphocytes. HSCs may be manipulated under different conditions. Advances in cell biology result in a better understanding of the relationship between viruses/bacteria and hematopoietic cells. Microbial infections can lead to profound disturbance of hematopoiesis. Infection may augment the production of cytokines, with proliferation and differentiation of the stem cells. Alternatively, infection may lead to destruction of progenitor cells. This results in defective hematopoiesis in certain infections. Since circulating CD34+ cells represent a distinct progenitor pool responsible for seeding extramedullary sites of hematopoiesis, infected peripheral blood-derived CD34+ progenitor cells may serve to disseminate pathogens into diverse anatomic sites. Therefore, progenitor cell infection may additionally effect long-term functional consequences within extramedullary sites of lymphopoiesis. A variety of viruses have been reported to target HSCs, whereas quiescent human HSCs are fully resistant to infection by different bacteria. For susceptibility of HSCs to infectious agents pathogen-receptor interaction plays an important role in virus/bacteria tropism and pathogenesis.
Post to CiteULike 
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
