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2003:
Mansueto P; Rizzo M; Affronti M; Malta R; Carmina E; Mansueto S; Masellis M; Rini G B
Safe and successful endoarterial infusion of liposomal amphotericin B in treatment of mucormycosis.
The new microbiologica : official journal of the Italian Society for Medical, Odontoiatric, and Clinical Microbiology (SIMMOC) 2003;
26(
4):.
Mucormycosis is a rare invasive mycotic infection treated by antifungini or amphotericin B. We describe the case of a patient with septic fever and a necrotic lesion, with phlegmon of medial left thigh. Surgery was performed to drain the abscess content and to remove the necrotic tissue; mucormycosis was diagnosized by histological and culture tests and treated by intravenous amphotericin B. Since the lesion worsened, liposomal amphotericin B was directly infused into the left common iliac artery, with progressive improvement, and treatment was continued until complete recovery. Therefore, the endoarterial infusion of liposomal amphotericin B was a safe and successful treatment of advanced lesions of mucormycosis. In such lesions, intravenous general antibiotic administration probably is not sufficient to reach the whole infected area.
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