Username


Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:
  • Over 1.500.000 Profiles
  • More than 1.800 Organizations worldwide
  • State of the Art Network Visualizations
  • Manage your own Profile
  • Locate Experts in your Country/Region
  • Locate Experts in your 1. and 2. Level Network
  • Connect to Experts Worldwide

find experts for

Sign-in to see more
2003: Asea Alexzander
Chaperokine-induced signal transduction pathways.
Exercise immunology review 2003;9():25-33.
A turning point in understanding the function of heat shock proteins (HSP) on components of the immune system has now begun. From their original description as intracellular molecular chaperones of naïve, aberrantly folded or mutated proteins and primarily involved in cytoprotection in response to stressful stimuli, in recent years, new functions of HSP have been revealed. Strong evidence now exists demonstrating that the seventy-kDa heat shock protein (HSP70) exits mammalian cells not only following necrotic cell death but also by a process involving its active release in response to stresses including cytokines, acute psychological stress and exercise. The released extracellular HSP70 interacts with cells of the immune system and exerts immunoregulatory effects--known as the chaperokine activity of HSP70. The chaperokine activity of HSP70 is mediated in part by utilizing surface receptors for both Toll-like receptor-2 (TLR2; receptor for Gram-positive bacteria) and TLR4 (receptor for Gram-negative bacteria) in a CD14-dependent fashion. These findings suggest an important role for heat shock proteins in host protection against pathogenic infection. This review will briefly discuss chaperokine-induced signaling and its relevance to infection and exercise.

Sign in free and see...

Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more