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2004:
Levin Frances Rudnick; McDowell David; Evans Suzette M; Nunes Edward; Akerele Evaristo; Donovan Stephen; Vosburg Suzanne K
Pharmacotherapy for marijuana dependence: a double-blind, placebo-controlled pilot study of divalproex sodium.
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions 2004;
13(
1):.
There is a noticeable lack of targeted treatment options for marijuana dependence, in particular pharmacologic approaches. This is the first study evaluating a targeted pharmacologic approach for marijuana dependence. The goals of the study were to determine if such patients would seek pharmacologic treatment, whether these patients could be retained in treatment using a design previously developed for cocaine-dependent patients, and especially whether divalproex sodium showed promise as a treatment agent for marijuana dependence. We found that marijuana-dependent patients will seek treatment, and such patients can be adequately maintained in a pharmacologic trial. Regardless of treatment group, patients reported a significant reduction in their frequency and amount of marijuana use as well as a reduction in irritability. Given the lack of proven effective treatments for marijuana dependence, pharmacotherapies should be sought. The design of a preliminary clinical trial should include a psychosocial/behavioral intervention emphasizing motivation and medication compliance and a placebo control group.
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