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2004:
Lamfers Martine L M; Hemminki Akseli
Multicellular tumor spheroids in gene therapy and oncolytic virus therapy.
Current opinion in molecular therapeutics 2004;
6(
4):.
Multicellular clusters of cells, or spheroids, can be grown and sustained in vitro, facilitating various cancer research and treatment approaches. As spheroids are three-dimensional and retain many of the cell types and features present in the original clinical tissues, they provide an important link between two-dimensional cell lines and in vivo xenograft studies. With regards to gene therapy and replication-competent oncolytic viruses in particular, spheroids allow sustained viability of primary tumor cells in vitro, a requirement for reliable analysis of replication. Analysis of clinical samples is of paramount importance for preclinical evaluation of candidate anticancer agents.
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