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2002:
Isozaki Masanao; Ito Kousei; Masubuchi Yasuhiro; Horie Toshiharu
Plasma retinol binding protein for monitoring the acetaminophen-induced hepatotoxicity.
Drug metabolism and pharmacokinetics 2002;
17(
6):.
Retinol-binding protein (RBP) is a specific transport protein which carries retinol in the circulation. RBP concentration in plasma and liver of rats following a large dose of acetaminophen (APAP) intraperitoneally was examined. The RBP concentration in plasma decreased significantly at 12 hr after the APAP administration, while the plasma albumin concentration was affected a little. Western blot and northern blot analyses showed marked changes in RBP but not in albumin. Thus, RBP was suggested to be more sensitive for the acute drug-induced hepatotoxicity than albumin. The decrease of RBP concentration in plasma was suggested to be caused by the dysfunction of RBP synthesis in the liver.
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