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2005:
Adewoye Adeboye H; Klings Elizabeth S; Farber Harrison W; Palaima Elizabeth; Bausero Maria A; McMahon Lillian; Odhiambo Adam; Surinder Safaya; Yoder Mark; Steinberg Martin H; Asea Alexzander
Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
American journal of hematology 2005;
78(
3):.
Inflammation may play an important role in the pathophysiology of sickle cell disease (SCD), and recent studies have identified the 70-kDa heat shock protein (Hsp70) as an important mediator of inflammatory responses. Here we demonstrate a significant increase in circulating serum Hsp70 level in SCD during vaso-occlusive crisis (VOC) as compared with baseline steady-state levels (P <0.05) and a significant increase in Hsp70 levels in SCD at baseline compared with normal controls (P <0.05). Taken together, these results indicate that circulating serum Hsp70 might be a marker for VOC in SCD.
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