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2005:
Graphodatsky Alexander S; Kukekova Anna V; Yudkin Dmitry V; Trifonov Vladimir A; Vorobieva Nadezhda V; Beklemisheva Violetta R; Perelman Polina L; Graphodatskaya Daria A; Trut Lyudmila N; Yang Fengtang; Ferguson-Smith Malcolm A; Acland Gregory M; Aguirre Gustavo D
The proto-oncogene C-KIT maps to canid B-chromosomes.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2005;
13(
2):.
Plant and animal karyotypes sometimes contain variable elements, that are referred to as additional or B-chromosomes. It is generally believed that B-chromosomes lack major genes and represent parasitic and selfish elements of a genome. Here we report, for the first time, the localization of a gene to B-chromosomes of mammals: red fox (Vulpes vulpes) and two subspecies of raccoon dog (Nyctereutes procyonoides). Identification of the proto-oncogene C-KIT on B-chromosomes of two Canidae species that diverged from a common ancestor more than 12.5 million years ago argues against the current view of B-chromosomes. Analyses of fox B-chromosomal C-KIT gene from a flow-sorted fox B-chromosome-specific library revealed the presence of intron-exon boundaries and high identity between sequenced regions of canine and fox B-chromosomal C-KIT copies. Identification of C-KIT gene on all B-chromosomes of two canid species provides new insight into the origin and evolution of supernumeraries and their potential role in the genome.
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