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2005:
Pu Jian-Xin; Xiao Wei-Lie; Lu Yang; Li Rong-Tao; Li Hong-Mei; Zhang Li; Huang Sheng-Xiong; Li Xian; Zhao Qin-Shi; Zheng Qi-Tai; Sun Han-Dong
Kadlongilactones A and B, two novel triterpene dilactones from Kadsura longipedunculata possessing a unique skeleton.
Organic letters 2005;
7(
22):.
[structure: see text] Two novel triterpene dilactones with an unprecedented rearranged hexacyclic skeleton, kadlongilactones A (1) and B (2), have been isolated from the leaves and stems of Kadsura longipedunculata Finet et Gagnep (Schisandraceae). Their structures were established by comprehensive 1D and 2D NMR spectroscopic analysis, coupled with single-crystal X-ray crystallographic diffraction. Compounds 1 and 2 exerted significant inhibitory effects against human tumor K562 cells with IC(50) = 1.40 and 1.71 microg/mL, respectively.
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