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2005:
Huang Sheng-Xiong; Zhao Qin-Shi; Xu Gang; Xiao Wei-Lie; Li Rong-Tao; Hou Ai-Jun; Peng Shu-Lin; Ding Li-Sheng; Sun Han-Dong
ent-Kaurane Diterpenoids from Isodon albopilosus.
Journal of natural products 2005;
68(
12):.
Nine new diterpenoids, albopilosins B-J (1-9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1-9 were established using spectroscopic methods including extensive 1D and 2D NMR analysis. The diterpenoids isolated were evaluated for their inhibitory activities against HepG2 (hepatoma) cells. Compounds 7 and 13 were the most active, with both having IC(50) values of <15 microM.
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