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2006:
Roberts Angela J; Wiedmann Martin
Allelic exchange and site-directed mutagenesis probe the contribution of ActA amino-acid variability to phosphorylation and virulence-associated phenotypes among Listeria monocytogenes strains.
FEMS microbiology letters 2006;
254(
2):.
To test the hypothesis that actA allelic variation contributes to virulence differences among Listeria monocytogenes strains, cell-to-cell spread and intracellular ActA phosphorylation patterns were characterized for 14 wild-type isolates and selected isogenic mutants. Our data show that (i) while actA allelic variation is not responsible for enhanced cell-to-cell spread observed in epidemic clone I strains, actA allelic variation may contribute to reduced plaque size observed in some isolates, (ii) actA sequence alone determines phosphorylation-dependent ActA banding patterns, and (iii) sequence variation at the positively selected ActA residue 498 does not contribute to ActA phosphorylation patterns or to differences in cell-to-cell spread.
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