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2006:
Xiao Wei-Lie; Yang Liu-Meng; Gong Ning-Bo; Wu Li; Wang Rui-Rui; Pu Jian-Xin; Li Xiao-Li; Huang Sheng-Xiong; Zheng Yong-Tang; Li Rong-Tao; Lu Yang; Zheng Qi-Tai; Sun Han-Dong
Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities.
Organic letters 2006;
8(
5):.
[STRUCTURE: SEE TEXT] Rubriflordilactones A (1) and B (2), two novel highly unsaturated rearranged bisnortriterpenoids possessing a biosynthetically modified aromatic D-ring, were isolated from the leaves and stems of Schisandra rubriflora. Their structures were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Compound 1 showed weak anti-HIV-1 activity, and compound 2 exhibited an EC50 value of 9.75 microg/mL (SI=12.39) against HIV-1 replication with low cytotoxicity.
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