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2006:
Smyth Mark J; Hayakawa Yoshihiro; Cretney Erika; Zerafa Nadeen; Sivakumar Pallavur; Yagita Hideo; Takeda Kazuyoshi
IL-21 enhances tumor-specific CTL induction by anti-DR5 antibody therapy.
Journal of immunology (Baltimore, Md. : 1950) 2006;
176(
10):.
Tumor cell apoptosis is the basis of many cancer therapies, and tumor-specific T cells are the principal effectors of successful anti-tumor immunotherapies. In this study, we show that induction of tumor cell apoptosis by agonistic mAb against DR5, combined with delayed IL-21 treatment, suppressed tumor growth and pre-established tumor metastases. Synergistic effects of the combination were observed in several tumor models where the target tumor was sensitive to DR5-mediated apoptosis. IL-21 promoted tumor-specific CTL activity and enhanced memory responses to tumor rechallenge. These results indicate that a rational combination of Ab-based therapy that causes tumor cell apoptosis and a cytokine that promotes T cell memory is a useful new strategy for cancer immunotherapy.
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