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2006:
Li Li-Mei; Li Guo-You; Huang Sheng-Xiong; Xiao Wei-Lie; Liao Xun; Lou Li-Guang; Ding Li-Sheng; Sun Han-Dong
Antiproliferative ent-Kauranoids from Isodon parvifolius.
Planta medica 2006;
72(
8):.
Nine new 7alpha,20-epoxy- ENT-kaurane diterpenoids, parvifolines O - W (1 - 9), together with five known analogues, lasiocarpanin (10), rosthorin A (11), longikaurin E (12), adenolin D (13) and longikaurin B (14), were isolated from the leaves of Isodon parvifolius. Their structures were determined by means of spectroscopic analysis. Selected diterpenoids (1 - 10) were tested for their antiproliferative activity against A549, HT-29 and K562 cells. Compounds 3, 7, 8 and 10 showed moderate inhibitory activity against all three cell lines.
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