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2006:
Corzana Francisco; Busto Jesús H; Engelsen Søren B; Jiménez-Barbero Jesús; Asensio Juan L; Peregrina Jesús M; Avenoza A
Effect of beta-O-glucosylation on L-Ser and L-Thr diamides: a bias toward alpha-helical conformations.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;
12(
30):.
Beta-D-O-glucosylation produces a remarkable effect on the peptide backbone of the model peptides derived from serine and threonine. Consequently, this type of glycosylation is responsible for the experimentally observed shift from extended conformations (model peptides) towards the folded conformations (model glycopeptides). The conclusion has been solidly assessed by a combined NMR/MD protocol. Interestingly, the MD (molecular dynamics) results for the glycopeptides point towards the existence of water-bridging molecules between the sugar and peptide moieties, which could explain the stabilization of the folded conformers in aqueous solution.
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