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2006: Pawlak Krystyna; Pawlak Dariusz; Mysliwiec Michal
Inflammation but not oxidative stress is associated with beta-chemokine levels and prevalence of cardiovascular disease in uraemic patients.
Cytokine 2006;35(5-6):258-62.
Inflammation and oxidative stress (SOX) have been reported in patients with chronic renal failure (CRF), but their influence on beta-chemokines levels and cardiovascular disease (CVD) prevalence remains unknown. We assessed beta-chemokines, SOX markers and high sensitivity C-reactive protein (hs CRP) as a marker of inflammation in 40 uraemic patients, both with as well as without CVD and 20 controls. Compared with the controls, the patients with CVD showed a significant increase in plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), total peroxide (both p<0.05), macrophage inflammatory protein 1beta (MIP-1beta) and hs CRP (both p<0.01). The values of MCP-1 and hs CRP were more elevated in patients with CVD than without CVD (p<0.01 and p<0.05; respectively). Both subgroup of CRF patients were lower of regulated upon activation, normal T cell expressed and secreted (RANTES) levels than in the controls (both p<0.001). The positive relationships were between hs CRP and presence of CVD, MIP-1beta (both p<0.01) and MCP-1 levels (p<0.05). SOX markers did not show any significant correlation with beta-chemokines, hs CRP and presence of CVD. We documented that increased inflammation but not SOX were associated with significant elevation in plasma beta-chemokines levels and CVD prevalence in CRF patients not requiring dialysis.

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