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2007Kuckleburg Christopher J; Elswaifi Shaadi F; Inzana Thomas J; Czuprynski Charles J
Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.
Infection and immunity 2007;75(2):1045-9.
Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP(-) H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

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