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2007Huang Sheng-Xiong; Pu Jian-Xin; Xiao Wei-Lie; Li Li-Mei; Weng Zhi-Ying; Zhou Yan; Han Quan-Bin; Peng Shu-Lin; Ding Li-Sheng; Lou Li-Guang; Sun Han-Dong
ent-Abietane diterpenoids from Isodon rubescens var. rubescens.
Phytochemistry 2007;68(5):616-22.
ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells.

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