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2006:
Matsunaga Takuya; Sato Tsutomu; Iyama Satoshi; Tanaka Shingo; Murase Kazuyuki; Sato Yasushi; Kobune Masayoshi; Takimoto Rishu; Kato Junji; Kuroda Hiroyuki; Niitsu Yoshiro
[Peripheral T-cell lymphoma presenting with eosinophilia due to interleukin-5 produced by lymphoma cells]
[Rinsho ketsueki] The Japanese journal of clinical hematology 2006;
47(
11):.
A 72-year-old male was admitted to our hospital to determine the cause of neck lymphadenopathies. He was diagnosed pathologically by a lymph node biopsy as having peripheral T-cell lymphoma (PTCL). He also had developed eosinophilia and his serum concentration of Interleukin-5 (IL-5) was extremely high. Immunostaining of a resected lymph node revealed that there were lymphoma cells which were stained with anti-IL-5 antibody. After 2 courses of CHOP therapy, the lymphadenopathies and eosinophilia disappeared and the concentration of serum IL-5 was normalized. It was suggested that IL-5 produced by lymphoma cells had induced his eosinophilia.
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