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2007:
De Lamo Marin Sandra; Xu Yang; Meijler Michael M; Janda Kim D
Antibody catalyzed hydrolysis of a quorum sensing signal found in Gram-negative bacteria.
Bioorganic & medicinal chemistry letters 2007;
17(
6):.
N-(3-Oxo-acyl) homoserine lactones are used by Gram-negative bacteria to signal the establishment of specific population densities and coordinate population-wide gene expression. Herein we report the antibody-catalyzed hydrolysis of N-(3-oxo-acyl) homoserine lactone (AHL) using a reactive immunization strategy with a squaric monoester monoamide hapten. Kinetic analysis of the most efficient antibody revealed a modest k(cat), with AHL hydrolysis competitively inhibited by original squaric monoester monoamide hapten. These studies suggest that antibody catalysis could provide a new avenue for blocking quorum sensing in bacteria.
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