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2007:
Stein Andrew M; Nowicki Michal O; Demuth Tim; Berens Michael E; Lawler Sean E; Chiocca E Antonio; Sander Leonard M
Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro.
Applied optics 2007;
46(
22):.
To gain insight into brain tumor invasion, experiments are conducted on multicellular tumor spheroids grown in collagen gel. Typically, a radius of invasion is reported, which is obtained by human measurement. We present a simple, heuristic algorithm for automated invasive radii estimation (AIRE) that uses local fluctuations of the image intensity. We then derive an analytical expression relating the image graininess to the cell density for a model imaging system. The result agrees with the experiment up to a multiplicative constant and thus describes a novel method for estimating the cell density from bright-field images.
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