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2008:
Reece Stephen T; Kaufmann Stefan H E
Rational design of vaccines against tuberculosis directed by basic immunology.
International journal of medical microbiology : IJMM 2008;
298(
1-2):.
Tuberculosis represents a serious problem for public health worldwide, and effective vaccines are urgently required. This represents a significant challenge as the causative bacterial agent, Mycobacterium tuberculosis, has developed strategies to persist in infected hosts despite the presence of potent T-cell-mediated immune responses. New advances in basic immunology are giving us improved understanding of what constitutes a protective immune response and ways this response is manipulated by the bacillus. Such insights should inform us how to design more effective vaccination strategies against intracellular pathogens.
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