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2008:
Pu Jian-Xin; Yang Liu-Meng; Xiao Wei-Lie; Li Rong-Tao; Lei Chun; Gao Xue-Mei; Huang Sheng-Xiong; Li Sheng-Hong; Zheng Yong-Tang; Huang Hao; Sun Han-Dong
Compounds from Kadsura heteroclita and related anti-HIV activity.
Phytochemistry 2008;
69(
5):.
Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC50 values of 1.6 microg/mL, and 1.4 microg/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra.
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