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2008:
Gao Xue-Mei; Pu Jian-Xin; Huang Sheng-Xiong; Yang Liu-Meng; Huang Hao; Xiao Wei-Lie; Zheng Yong-Tang; Sun Han-Dong
Lignans from Kadsura angustifolia.
Journal of natural products 2008;
71(
4):.
Phytochemical investigation of Kadsura angustifolia led to the isolation and identification of 26 lignans and two triterpenoids, including 11 new lignans named kadangustins A-K ( 1- 11). The structures and stereochemistry of 1- 11 were elucidated by analysis of spectroscopic data. Except for 11 and 20, all the lignans were evaluated for their inhibitory activity against HIV-1. Binankadsurin A ( 19) showed anti-HIV activity with an EC 50 value of 3.86 microM.
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