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2008:
Brown Robert; Zlatescu Magdalena; Sijben Angelique; Roldan Gloria; Easaw Jay; Forsyth Peter; Parney Ian; Sevick Robert; Yan Elizabeth; Demetrick Douglas; Schiff David; Cairncross Gregory; Mitchell Ross
The use of magnetic resonance imaging to noninvasively detect genetic signatures in oligodendroglioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;
14(
8):.
BACKGROUND: Some patients with low-grade glioma have extraordinarily long survival times; current, early treatment does not prolong their lives. For this reason, therapies that sometimes have neurologic side effects are often deferred intentionally. METHODS: In a study of oligodendrogliomas, we used a quantitative method of MR analysis based on the S-transform to investigate whether codeletion of chromosomes 1p and 19q, a marker of good prognosis, could be predicted accurately by measuring image texture. RESULTS: Differences in texture were seen between tumors with codeletion of chromosomes 1p and 19q and those with intact 1p and 19q alleles on contrast-enhanced T1-weighted and T2-weighted MR images. Quantitative MR texture on T2 images predicted codeletion of chromosomes 1p and 19q with high sensitivity and specificity. CONCLUSIONS: This new method of MR image interpretation may have the potential to augment the diagnostic assessment of patients with suspected low-grade glioma.
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