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2008:
Palomo Claudio; Aizpurua Jesus M; Balentová Eva; Azcune Itxaso; Santos J Ignacio; Jiménez-Barbero Jesús; Cañada Javier; Miranda José Ignacio
"Click" saccharide/beta-lactam hybrids for lectin inhibition.
Organic letters 2008;
10(
11):.
Hybrid glycopeptide beta-lactam mimetics designed to bind lectins or carbohydrate recognition domains in selectins have been prepared according to a "shape-modulating linker" design. This approach was implemented using the azide-alkyne "click" cycloaddition reaction, and as shown by NMR/MD experiments, binding of the resulting mimetics to Ulex Europaeus Lectin-1 (UEL-1) occurred after a "bent-to-extended" conformational change around a partially rotatable triazolylmethylene moiety.
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