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2008:
Lim Yong-Beom; Kwon Oh-Joon; Lee Eunji; Kim Pyung-Hwan; Yun Chae-Ok; Lee Myongsoo
A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier.
Organic & biomolecular chemistry 2008;
6(
11):.
We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a beta-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors.
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