Username


Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:
  • Over 1.500.000 Profiles
  • More than 1.800 Organizations worldwide
  • State of the Art Network Visualizations
  • Manage your own Profile
  • Locate Experts in your Country/Region
  • Locate Experts in your 1. and 2. Level Network
  • Connect to Experts Worldwide

find experts for

Sign-in to see more
2008: de Boo Hendrina A; Eremia Simona C; Bloomfield Frank H; Oliver Mark H; Harding Jane E
Treatment of intrauterine growth restriction with maternal growth hormone supplementation in sheep.
American journal of obstetrics and gynecology 2008;199(5):559.e1-9.
OBJECTIVE: This study was undertaken to investigate whether maternal growth hormone supplementation in pregnant sheep could reverse intrauterine growth restriction (IUGR) induced by placental embolization. STUDY DESIGN: Animals were randomized into control, intrauterine growth restriction + saline or intrauterine growth restriction + growth hormone (twice daily injections of 0.1 mg/kg growth hormone) groups. Intrauterine growth restriction was induced by twice daily placental embolization between 93 and 99 days' gestation, and treatment was from 100-128 days' gestation (term = 147 days' gestation). RESULTS: Embolization reduced fetal growth rate and body weight but increased brain-to-liver weight ratio. Growth hormone treatment significantly increased fetal growth rates and fat deposition, and improved fetal body weight and length, but not liver weight. Growth hormone treatment produced hydranencephalic brain lesions in some fetuses. CONCLUSION: Maternal growth hormone treatment partially reversed intrauterine growth restriction caused by placental insufficiency. However, the possible connection between growth hormone treatment and fetal brain injury requires further investigation.

Post to CiteULike

Sign in free and see...

Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more