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2008:
Pu Jian-Xin; Gao Xue-Mei; Lei Chun; Xiao Wei-Lie; Wang Rui-Rui; Yang Li-Bin; Zhao Yong; Li Li-Mei; Huang Sheng-Xiong; Zheng Yong-Tang; Sun Han-Dong
Three new compounds from Kadsura longipedunculata.
Chemical & pharmaceutical bulletin 2008;
56(
8):.
Two new tetrahydrofuran lignans, kadlongirins A and B (1, 2), a new cadinane-type sesquiterpenoid, 2,7-dihydroxy-11,12-dehydrocalamenene (3), together with seven known lignans, grandisin, fragransin B1, vladirol F, kadsuralignan C, otobaphenol, isoanwulignan, and 4-[4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-2-methoxy-phenol, were isolated from the leaves and stems of Kadsura longipedunculata. The structures of these new compounds were elucidated by spectroscopic methods. Compound 2 exhibited weak anti-human immunodeficiency virus-1 activity with an EC50 value of 16.0 microg/ml, and therapeutic index (TI) value of 6.7.
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