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2008:
Bryce Alan H; Ketterling Rhett P; Gertz Morie A; Lacy Martha; Knudson Ryan A; Kumar Shaji; Kyle Robert A; Fonseca Rafael; Greipp Phillip R; Lust John A; Rajkumar Vincent S; Hayman Suzanne R; Buadi Francis; Russell Stephen J; Zeldenrust Stephen R; Dispenzieri Angela
A novel report of cig-FISH and cytogenetics in POEMS syndrome.
American journal of hematology 2008;
83(
11):.
POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.
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