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2008: Takada Kohichi; Kato Junji; Kawano Yutaka; Takahashi Sho; Hayashi Tsuyoshi; Ishiwatari Hirotoshi; Miyanishi Koji; Takimoto Rishu; Kobune Masayoshi; Sagawa Tamotsu; Sato Tsutomu; Sato Yasushi; Yamashita Toshiharu; Natori Hiroshi; Niitsu Yoshiro
[Effective CDDP arterial infusion with DSM for liver metastasis of malignant melanoma complicating DIC due to intratumoral hemorrhage--a case report]
Gan to kagaku ryoho. Cancer & chemotherapy 2008;35(10):1803-5.
A 65-year-old male, who had been diagnosed with melanoma of stage IIB and treated by chemotherapy since 2003 at the Dermatology Department, was referred to our department for liver metastasis of melanoma that had become resistant to chemotherapeutic agents. In 2006, he started receiving hepatic arterial infusion of CDDP. He was admitted to the hospital on an emergency basis for general fatigue the next May. Blood tests revealed anemia and thrombocytopenia. Contrast CT showed aggravation of liver metastasis. Contrast ultrasonography revealed nodular contrast enhancement at the margin of the tumor. On the basis of image findings and blood test results, DIC due to intratumoral hemorrhage was diagnosed. CDDP arterial infusion with DSM resulted in improved DIC, and he was able to be discharged. Taken together, attention has to be paid to the potential for emergency complications of DIC due to liver metastasis of melanoma with intratumoral hemorrhage. Moreover, it was shown that arterial infusion with DSM was effective for liver metastasis of melanoma.

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