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2008Ortega Eugenia; Marti Rosa M; Yeramian Andree; Sorolla Anabel; Dolcet Xavier; Llobet David; Abal Leandro; Santacana Maria; Pallares Judit; Llombart-Cussac Antonio; Matias-Guiu Xavier
Targeted therapies in gynecologic cancers and melanoma.
Seminars in diagnostic pathology 2008;25(4):262-73.
The article reviews the main molecular pathology alterations of endometrial and ovarian carcinomas and melanoma. Several promising drugs targeting the genes most frequently altered in these tumors are under consideration. The most promising signaling pathways to be targeted for therapies in these tumors are the tyrosine kinase receptor (EGFR, HER2, c-KIT), the RAS/B-RAF/MAPK, the PI3K-mTOR, and apoptosis signaling pathways.

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