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2009:
Zhao Yong; Huang Sheng-Xiong; Yang Li-Bin; Pu Jian-Xin; Xiao Wei-Lie; Li Li-Mei; Lei Chun; Weng Zhi-Ying; Han Quan-Bin; Sun Han-Dong
Cytotoxic ent-kaurane diterpenoids from Isodon henryi.
Planta medica 2009;
75(
1):.
Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ENT-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ENT-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values<0.50 microg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.
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