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2009:
Minster Ryan L; Demirci F Yesim; DeKosky Steven T; Kamboh M Ilyas
No association between CALHM1 variation and risk of Alzheimer disease.
Human mutation 2009;
30(
4):.
A polymorphism in the calcium homeostasis modulator 1 gene (CALHM1) has recently been associated with risk of late-onset Alzheimer disease. We examined this variant (rs2986017) in 945 Caucasian Americans with late-onset Alzheimer disease and 875 age-matched Caucasian American controls. No association with risk of late-onset Alzheimer disease (p=0.368 for genotypes; p=0.796 for alleles) was observed in our sample. However, a potential modest association of minor allele homozygosity (TT) with an earlier age-at-onset was seen (p=0.034).
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