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2009:
Wallecha Anu; Carroll Kyla Driscoll; Maciag Paulo Cesar; Rivera Sandra; Shahabi Vafa; Paterson Yvonne
Multiple effector mechanisms induced by recombinant Listeria monocytogenes anticancer immunotherapeutics.
Advances in applied microbiology 2009;
66(
):.
Listeria monocytogenes is a facultative intracellular gram-positive bacterium that naturally infects professional antigen presenting cells (APC) to target antigens to both class I and class II antigen processing pathways. This infection process results in the stimulation of strong innate and adaptive immune responses, which make it an ideal candidate for a vaccine vector to deliver heterologous antigens. This ability of L. monocytogenes has been exploited by several researchers over the past decade to specifically deliver tumor-associated antigens that are poorly immunogenic such as self-antigens. This review describes the preclinical studies that have elucidated the multiple immune responses elicited by this bacterium that direct its ability to influence tumor growth.
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