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2009:
Gabeau-Lacet Darlene; Aghi Manish; Betensky Rebecca A; Barker Fred G; Loeffler Jay S; Louis David N
Bone involvement predicts poor outcome in atypical meningioma.
Journal of neurosurgery 2009;
111(
3):.
OBJECT: The authors identified clinical features associated with progression and death in atypical meningioma (AM). METHODS: Forty-seven cases of primary AM treated at Massachusetts General Hospital were retrospectively evaluated for clinical features. Associations with progression-free survival (PFS) and overall survival were assessed. RESULTS: The estimated median PFS was 56 months (95% CI 35 months-not estimable). The overall 3- and 5-year PFS rates were 65% (95% CI 44-80%) and 48% (95% CI 26-67%), respectively. The median survival time and 5- and 10-year survival rates were 158 months (95% CI 103 months-not estimable), and 86% (95% CI 69-94%) and 61% (95% CI 35-79%), respectively. Subtotal resection was associated with increased rate of progression compared to gross-total resection (p=0.05) and trended toward an association with decreased survival (p=0.09). Bone involvement was associated with an increased rate of disease progression (p=0.001) and decreased survival (p=0.04). Bone involvement remained significantly associated with progression after Bonferroni adjustment for multiple comparisons (p=0.008) and in bivariate Cox regression models. Seventy-eight percent of patients with bone involvement at primary diagnosis had tumor recurrence within bone, whereas only 25% of patients without evidence of bone invasion at primary diagnosis experienced osseous recurrence. CONCLUSIONS: Osseous involvement is associated with a poor outcome in patients with AMs; bone assessment is therefore extremely important. Further investigation is warranted to assess the effectiveness of bone resection and/or bone-directed radiation therapy in improving outcome.
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