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2009:
Ghobrial Irene M; Leleu Xavier; Azab Abdel Kareem; Runnels Judith; Jia Xiaoying; Ngo Hai; Melhem Molly; Azab Feda; Sacco Antonio; Quang Phong; Burwick Nicholas; Moreau Anne-Sophie; Husu Emanuel; Farag Mena; Roccaro Aldo
Novel therapeutic agents in Waldenström's macroglobulinemia.
Clinical lymphoma & myeloma 2009;
9(
1):.
Within the past few years, major advances in the preclinical and clinical testing of novel therapeutic agents have occurred in Waldenström's macroglobulinemia (WM). These include agents that target the PI3K/Akt/mTOR pathway, PKC pathways, NF-kB signaling pathway, as well as tyrosine kinases and histone deacetylase inhibitors. In this review, we summarize the current understanding of the clinical development of these agents in WM.
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