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1989:
Geula C; Mesulam M
Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease.
Brain research 1989;
498(
1):.
Selective cholinesterase inhibitors such as BW284C51 and iso-OMPA showed that the plaques and tangles of Alzheimer's disease contain acetylcholinesterase and butyrylcholinesterase activity. In comparison to the cholinesterases of the normal brain, the plaque and tangle-bound cholinesterases in Alzheimer's disease display major shifts in optimum pH and inhibitor sensitivity.
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